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Evidence from lots of epidemiological studies suggests that tall intakes of fruits and vegetables are connected with a condensed risk of cardiovascular disease .This association might be partly attributable to the antioxidant content of these foods because oxidation hurt, including oxidation modification of low-density proteins, is a major cause of cardiovascular disease .In addition to its antioxidant properties, vitamin C has been shown to reduce mono cot observance to the endothelial, improve endothelial-dependent citric oxide production and dilatation, and reduce vascular smooth-muscle-cell apoptosis, which prevents plaque volatility in atherosclerosis .Results from forthcoming studies exploratory associations between vitamin C intake and cardiovascular infection risk are inconsistent .In the Nurses' Health Study, a 16-year probable study involving 85,118 female nurses, total intake of vitamin C from both dietary and supplemental source was inversely associated with coronary heart disease risk .However, intake of vitamin C from diet alone showed no significant relatives, suggesting that vitamin C harmonize users might be at lesser peril of coronary heart disease. A much smaller study indicated that postmenopausal women with diabetes who took at least 300 mg/day vitamin C supplements had increased cardiovascular disease mortality. A potential study in 20,649 British adults originate that those in the top quarterly of baseline plasma vitamin C concentrations had a 42% lower risk of stroke than those in the base quarterly .In male physicians participating in the Physicians' Health Study, use of vitamin C supplements for a mean of 5.5 years was not associated with a significant decrease in total cardiovascular disease mortality or coronary heart disease death .A pooled analysis of nine prospective studies that included 293,172 subjects free of coronary heart disease at baseline found that people who took ≥700 mg/day of supplemental vitamin C had a 25% lower risk of coronary heart disease frequency than those who took no supplemental vitamin C .The authors of a 2008 meta-analysis of prospective cohort studies, including 14 studies reporting on vitamin C for a median follow-up of 10 years, concluded that dietary, but not supplemental, intake of vitamin C is inversely associated with coronary spirit disease danger .