Consequences from most medical
intervention trials have disastrous to show a beneficial consequence of vitamin
C supplementation on the chief or secondary preclusion of cardiovascular
disease. In the Women's Antioxidant Cardiovascular Study, a less vital
prevention trial involving 8,171 women elderly 40 years or older with a the
past of cardiovascular disease, supplementation with 500 mg/day vitamin C for a
mean of 9.4 years showed no overall effect on cardiovascular events .likewise,
vitamin C supplementation (500 mg/day) for a denote follow-up of 8 years had no
effect on main cardiovascular events in male physicians enrolled in the
Physicians' Health Study II .Other clinical trials have generally examined the
effects on cardiovascular disease of supplements combining vitamin C with other
antioxidants, such as vitamin E and beta-carotene, making it more difficult to
isolate the possible contribution of vitamin C. The SU.VI.MAX study examined
the property of a combination of vitamin C (120 mg/day), vitamin E (30 mg/day),
beta-carotene (6 mg/day), selenium (100 mcg/day), and zinc (20 mg/day) in
13,017 French adults from the general inhabitants .After a center take notes
time of 7.5 years, the combined supplements had no result on ischemic
cardiovascular disease in either men or women. In the Women's Oceanographic
Vitamin and Estrogen (WAVE) study, involving 423 postmenopausal women with at
least one coronary stenos is of 15%–75%, supplements of 500 mg vitamin C plus
400 IU vitamin E twice per day not only provided no cardiovascular benefit, but
significantly increased all-cause mortality compare with placebo .
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